Glomerular injury responses to SCA are strongly modified by the Fib γ^390-396domain. RNA-sequencing analyses of glomerular fractions of kidney from the experimental mice 1 year posttransplant reveal chronic injury and loss of normal cellular programming in Fib^WT SS mice compared with the Fibγ^390-396A SS mice. Heatmap data and gene-ontology pathways showing differentially expressed transcripts in Fib^WT SS (n = 3) vs Fibγ^390-396A SS (n = 4) mice glomeruli. Fib^WT B6 (n = 2) and Fibγ^390-396A B6 (n = 3) mice glomeruli were used as control. The most significant enrichments among each of the clusters are indicated by color codes (ToppGene functional enrichments were determined using the complete clusters as shown in supplemental Table 3) and indicate perturbation of the biological processes in the Fib^WT SS and/or the Fibγ^390-396A SS group. Also see supplemental Figure 14 as well as supplemental Table 3 for expanded gene lists associated with each gene cluster. Differentially expressed genes were determined based on Welch ANOVA using a false discovery rate of 0.1 and fold-change >2 for any group comparison.