The incidence of severe Cfz-induced CVAEs according to the likelihood of LVDD detected using echocardiography. (A) Among patients with negative LVDD, 1 developed unstable angina that was successfully treated with percutaneous coronary intervention. Among patients with intermediate LVDD, 2 developed severe Cfz-induced CVAEs (acute heart failure and LVEF decrease), which improved immediately after the discontinuation of Cfz. (B) Time-to-event curves for severe Cfz-induced CVAEs according to the likelihood of LVDD: patients with negative, intermediate, and definite LVDD. **P < .01; ***P < .001. NS, not significant.