Elevated expression of STAT3β prolongs survival in an AML mouse model based on Pten deletion. (A) Kaplan-Meier plot showing the significantly different survival (P = .0034) of Pten^Δ/Δ (n = 16) and Pten^Δ/ΔStat3β^TG (n = 11) mice, with Pten^Δ/+ (n = 9) and Pten^Δ/+ Stat3β^TG (n = 11) as controls. (B) Percentages of myeloid (CD11b⁺Gr1⁺) and LSK cells in the BM and spleen of control, Pten^Δ/Δ, and Pten^Δ/ΔStat3β^TG mice at 10, 20, and 30 days postinduction (n = 5 per group). Data (Pten^Δ/+ vs Pten^Δ/Δ vs Pten^Δ/ΔStat3β^TG for each time point) were compared using 1-way analysis of variance. (C) H&E-stained liver and spleen sections of Pten^Δ/Δ, Pten^Δ/ΔStat3β^TG, and control mice at day 20 postinduction. *P < .05, **P < .01, ***P < .001.