Figure 5.
Figure 5. STAT3β prolongs survival and has a tumor-suppressive effect in MLL-AF9–dependent AML 6 weeks posttransplantation. (A) Kaplan-Meier plot of NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice receiving transplants of Stat3βTG and wt FLCs (n = 15 per group), showing significantly different survival (P = .0087). (B) WBC count and relative spleen weight and size. (C) Quantification by flow cytometry of myeloid Venus+ blasts in PB, BM, and spleen of Stat3βTG and wt mice. (D) H&E-stained liver and spleen sections and PB smears of wt and Stat3βTG animals. Quantifications shown as infiltrate area/total organ area (%) and number of blasts/total cell number (%). (B-D) Data were compared using the Student t test. *P < .05, **P < .01.

STAT3β prolongs survival and has a tumor-suppressive effect in MLL-AF9–dependent AML 6 weeks posttransplantation. (A) Kaplan-Meier plot of NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice receiving transplants of Stat3βTG and wt FLCs (n = 15 per group), showing significantly different survival (P = .0087). (B) WBC count and relative spleen weight and size. (C) Quantification by flow cytometry of myeloid Venus+ blasts in PB, BM, and spleen of Stat3βTG and wt mice. (D) H&E-stained liver and spleen sections and PB smears of wt and Stat3βTG animals. Quantifications shown as infiltrate area/total organ area (%) and number of blasts/total cell number (%). (B-D) Data were compared using the Student t test. *P < .05, **P < .01.

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