Tisagenlecleucel expansion kinetics. (A) Cellular kinetic plots demonstrating in vivo expansion and persistence of tisagenlecleucel in patients with CR at baseline. (B) Box plot of Cmax by response status at baseline (pharmacokinetic analysis set). Geometric mean Cmax (% coefficient variation) in patients with CR at baseline and in the rest of the patients was 5760 copies per microgram (112%) and 5790 copies per microgram (291%), respectively. Diamonds represent the mean and circles represent values outside of 1.5× interquartile range (IQR). Lower and upper whiskers extend to most extreme points within 1.5× IQR or quartile 1 and quartile 3, respectively. qPCR, quantitative polymerase chain reaction.