QoL assessment using SF-36 at baseline, week 12, and week 28 in SoC patients, SoC+ECP patients, andtime trend analysis for SF-36 subscores. Patients completed the SF-36 questionnaire for the assessment of QoL at baseline, week 12, and week 28. Median values for SoC patients (A) and SoC+ECP patients (B) are provided. Time trend analyses were performed post hoc. The SF-36 domains of QoL were scored from 0 to 100. (C) Negative estimate denotes decrease of QoL over time. *P < .009.