CRISPR screens identify candidates for genes whose inactivation confers CM resistance. (A-F) Gene level analysis of changes in sgRNA distribution in cell pools harvested at early times (day 13 for LEN or day 9 for POM and CC-122) (A,C,E) or late times (day 21) (B,D,F). The most relevant genes are highlighted and labeled using identical colors in all panels. (G) Venn diagram depicting overlap of most confident candidates for genes whose inactivation confers outright resistance against LEN, POM, or CC-122. Cutoffs used were FDR adjusted (adj). P < .05 and a median sgRNA fold change >2 on day 21.