Validation in DISCOVeRY-BMT of significant SNP associations in Martínez-Laperche et al report. This figure shows the ORs, 95% CIs, and P values as reported by Martínez-Laperche et al¹  (literature) and validation of these associations in DISCOVeRY-BMT cohort 1 and cohort 2. Martínez-Laperche et al reported 6 SNPs with P < .05 and 95% CIs that did not include OR = 1, which are shown along the y-axis. The results are grouped by those shown in the Martínez-Laperche et al report (literature) and DISCOVeRY-BMT (cohort 1 and cohort 2), as indicated in the gray boxes displayed along the top of the figure. Each circle, square, and triangle represents an OR from regression analysis, with the shapes corresponding to grade 2 to 4 aGVHD, grade 3 to 4 aGVHD, or NRM, respectively. The colors represent P values of the analyses: .05 > P ≥ .01 (blue) and P > .05 (red). rs2275913 and rs3819024 are donor variants; the remaining 4 SNPs are recipient associations. *SNPs with a 5% and **SNPs with a 10% difference in minor allele frequency (MAF) between DISCOVeRY-BMT and GETH, respectively; all other MAFs were comparable between the groups. For example, (recipient) SNP rs4711998 was associated with increased risk of grade 2 to 4 aGVHD in GETH (blue and to the right of OR = 1) but resides on OR = 1 and P > .05 in DISCOVeRY BMT.