The high-risk patient group classified by our predictive model demonstrated inferior clinical outcomes compared with the low-risk patient group in the validation cohort. (A) The high-risk (HR-GES) patient group classified by our predictive model (n = 9) had significantly inferior EFS by 5 years (53%) compared with the low-risk (LR-GES) patient group (83%; n = 79). (B) The EMR failure patient group classified by BCR-ABL1 percentage at 3 months (n = 11) had inferior EFS by 5 years (59%) compared with the EMR achievement patient group (83%; n = 77). (C) The high-risk patient group classified by our predictive model (n = 9) had significantly inferior FFS by 5 years (44%) when compared with the low-risk patient group (72%; n = 79). (D) The EMR failure patient group classified by BCR-ABL1 percentage at 3 months (n = 11) had inferior FFS by 5 years (45%) when compared with the EMR achievement patient group (73%; n = 77). All statistical analyses were performed using the log-rank test.