Figure 1.
Visual overview of posttransplant IR in terms of time and graft source. Comprehensive IR data are summarized in supplemental Table 2. (A-B) ALC and CD20+ B- cell, CD4+CD45RA+ T-cell, and NK-cell counts (expressed as CD3−CD56+ and CD16+CD57−) were significantly higher during the early phase in all UCB recipients (all P < .001). In contrast to NK cells, the observation of CD8+ T-cell recovery was delayed in UCB recipients compared with that in BM and PBSC recipients. However, CD4+ T-cell expansion was temporally confirmed in memory T-cell and effector T-cell subsets in UCB recipients, and the overall difference in graft source–related IR gradually decreased over time.