During permanent ischemic stroke, platelet CypD does not regulate infarct size or neurological and motor outcomes. Male and female CypD^plt−/− mice or littermate controls (CypD^plt+/+) were subjected to permanent (eg, 24 hours) cerebral ischemia (eg, pMCAO). (A) Representative brain sections stained with 2,3,5-triphenyl tetrazolium chloride. Healthy tissue stains red, whereas an absence of staining (white; arrows) indicates infarcted area. (B) Brain infarct volumes were quantified by planimetric analysis. (C) Neurological outcome was assessed using the Bederson test. (D) Motor function was examined using the grip strength test.