Synergistic interaction between BCL2i and MCL1i. (A-J) Cells isolated from 10 T-PLL patients were stimulated with IL-2, IL-4, and CD40L and treated with different concentrations of venetoclax and S63845 in combination for 24 hours before analysis of cell viability using CellTiter-Glo. All unstimulated (K) and stimulated (L) responses across all samples averaged. Experiments were performed in triplicate, and data shown are mean values. CI values <1 indicate synergy.