Mutational landscape. Explanatory tracks below sample names indicate the sampling point (diagnostic AP, BP, CP, or follow-up sample), treatment response for CP cases (poor, suboptimal, or optimal), expansion compartment (myeloid, lymphoid, or ambiguous) for AP/BP cases, sequencing strategy (WES or panel sequencing), variant calling strategy (tumor normal or tumor only), and control sample type (skin, T cells, or PMNC). The following tracks show mutation load calculated as number of SNVs per mbp (A), the number of SNVs identified in each sample by the consequence of the mutation (B), the number of small frameshift insertions and deletions identified in each sample by the consequence of the frameshift insertion and deletion (C), and the number of viral reads in each sample expressed as CPMs (D). Diagnostic samples from patients #22, #33, #41, #42 and follow-up sample from patient #42 were excluded from the analysis.