Landscape of relevant nonsilent variants at diagnosis. Potentially relevant nonsilent (ie, nonsynonymous SNVs and frameshifting insertions and deletions that were linked with cancer or occurred in genes that mutated in 2 or more patients) variants. Explanatory tracks from top to bottom show the sampling point (AP, BP, CP or follow-up sample), treatment response for CP cases (poor, suboptimal, or optimal), and expansion compartment (myeloid, lymphoid, or ambiguous) for AP/BP cases, sequencing strategy (WES, panel sequencing, or RNA sequencing), and variant calling strategy (tumor normal or tumor only). The color of the variant box indicates the type of mutation. The average expression of the genes in 7 AP/BP, 5 CP, and 4 healthy subjects are shown on the right, expressed as CPMs. Bar lengths indicate means and error bars repesent range. At the bottom, additional chromosomal abnormalities (ACA) found using karyotyping techniques are shown. *Patients with samples from both CP and AP/BP.