Landscape of relevant nonsilent variants in serial samples. Potentially relevant nonsilent variants (ie, nonsynonymous SNVs and frameshifting insertions and deletions that were linked with cancer or occurred in genes mutated in 2 or more patients). Explanatory tracks from top to bottom show the sampling point (BP, CP, or follow-up [FU] sample), treatment response for CP cases (poor, suboptimal, or optimal), sequencing strategy (WES, RNA sequencing, or panel sequencing), and sorting status of the sample (sorted CD34⁺ cells or unsorted MNCs). The color of the variant box indicates the type of mutation.