Landscape of identified TP53 mutations and other co-mutations. (A) Lollipop plot representing all identified mutations in TP53. Height of bar plot represents frequency of a specific mutation. Color of each mutation (circles) represents mutation type. Color of each gene region represents domains. (B) Frequency of identified mutations in other genes by amplicon-based next-generation sequencing. VAFs of identified mutations with median and range. Mutations are ordered by decreasing median VAF. (C) Frequencies of TP53 mutation, TP53 deletion, and complex karyotype among the entire patient cohort (n = 938).