Prognostic subgroups of patients with TP53-mutant MDS based on TP53 VAF and karyotype. Kaplan-Meier estimate curves for OS of patients based on the presence of TP53 mutation, complex karyotype, and TP53 deletion (A); the number of TP53 abnormalities defined as the sum of mutations and deletions (B); VAF of TP53 mutation (C); and VAF of TP53 mutation and presence of a complex karyotype (D). CCG, complex cytogenetics; LOH, loss of heterozygosity.