Figure 5
Vegfaa-engineered molecules block brain angiogenesis. (A) Confocal micrographs of 36- or 48-hpf uninjected (left) or vegfaa-121 E64A mRNA injected (right) embryos. Arrows point to PHBC, BA, and CtAs in the uninjected embryos and to reduced PHBC formation in the injected embryos. Asterisks denote lack of brain vasculature in the injected embryos. (B) Confocal micrographs of 48-hpf TgBAC(etv2:EGFP) vegfaabns1;vegfabbns92 double mutants uninjected (left) or vegfaa-121 E64 mRNA injected (right) embryos in dorsal views. Arrows point to PHBC in the uninjected embryos. Asterisks denote lack of brain vasculature in the injected embryos. Bars represent 100 µm.
