Figure 1.
Figure 1. Flow cytometry to diagnose paroxysmal nocturnal hemoglobinuria (PNH) and to quantitate the clone. / A. Demonstrates a population comprising 28% of the red cells that are completely deficient in CD59 (and other glycosylphosphatidylinositol (GPI)–linked antigens) and a second abnormal population of partially deficient red cells comprising 3.5% of the total. / B. Demonstrates the lack of more than one GPI-linked antigen (CD16 and CD24) from the same patient’s granulocytes. / C. Demonstrates that the proportion of PNH monocytes usually closely corresponds to the granulocyte analysis. (Courtesy of Dr. S.J. Richards)

Flow cytometry to diagnose paroxysmal nocturnal hemoglobinuria (PNH) and to quantitate the clone.

A. Demonstrates a population comprising 28% of the red cells that are completely deficient in CD59 (and other glycosylphosphatidylinositol (GPI)–linked antigens) and a second abnormal population of partially deficient red cells comprising 3.5% of the total.

B. Demonstrates the lack of more than one GPI-linked antigen (CD16 and CD24) from the same patient’s granulocytes.

C. Demonstrates that the proportion of PNH monocytes usually closely corresponds to the granulocyte analysis. (Courtesy of Dr. S.J. Richards)

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