(in Harousseau et al).ZHX-2expression is inversely correlated with expression of proliferation genes in 221 myeloma cases.

The expression level of ZHX-2 (top row) is ordered from the lowest level (blue) on the left to the highest level (red) on the right. Expression higher than the median (red) and lower than the median (blue) of proliferation genes (rows) is presented for each patient (columns). Note the inverse correlation of proliferation genes and ZHX-2. This data, combined with the facts that ZHX-2 negatively regulates NF-Y and ZHX-2 loss is linked with poor outcome, strongly implies that loss of ZHX-2 gene expression results in upregulation of proliferation genes, imparting poor prognosis.