Figure 3.
Stem cell homing to the endosteum. Homing of human CD34+/CXCR4+ stem cells from the blood circulation via the murine BM sinusoids to the endosteum. Key molecules involved in this process, reported in recent studies (in addition to P/E-selectins and SDF-1–activated LFA-1, VLA-4, VLA-5, and their ligands [Peled et al,98,99 Kollet et al,63 and Manfredini et al64 ] which were omitted for simplicity) are illustrated.