Electron microscopy of SARS-CoV–infected human DCs. Negative-contrast thin-section transmission electron micrograph of SARS-CoV–infected human DCs showed virus (black arrowheads) binding (A) and uptake (B) at 0 hours after infection. At 6 hours, 12 hours, and 24 hours after infection, virus particles were detected in endosomes (C) and cytoplasm (D) but not in the Golgi apparatus (E). No virus budding was observed (F) in all cells examined. Images are representative of SARS-CoV–infected human DCs from 3 independent adult or CB donors.