Figure 1.
Figure 1. Effect of KLF2 on endogenous murine α- and β-like globin gene expression in E10.5 yolk sac. GPA was used as an internal control. The globin/GPA mRNA ratio for the wild type is taken as 100%, and for the other genotypes it is expressed compared with 100%. n represents the number of embryos of each genotype used to determine the mean globin/GPA mRNA ratio. Error bars represent the standard deviation from the mean. *Statistically significant difference of expression in KLF2+/- or KLF2-/- embryos from the wild type; P < .025. (A) Expression of the embryonic Ey-globin gene in KLF2+/+, KLF2+/-, and KLF2-/- embryos; (B) expression of the embryonic βh1-globin gene in KLF2+/+, KLF2+/-, and KLF2-/- embryos; and (C) expression of the embryonic ζ-globin gene in KLF2+/+ and KLF2-/- embryos.

Effect of KLF2 on endogenous murine α- and β-like globin gene expression in E10.5 yolk sac.GPA was used as an internal control. The globin/GPA mRNA ratio for the wild type is taken as 100%, and for the other genotypes it is expressed compared with 100%. n represents the number of embryos of each genotype used to determine the mean globin/GPA mRNA ratio. Error bars represent the standard deviation from the mean. *Statistically significant difference of expression in KLF2+/- or KLF2-/- embryos from the wild type; P < .025. (A) Expression of the embryonic Ey-globin gene in KLF2+/+, KLF2+/-, and KLF2-/- embryos; (B) expression of the embryonic βh1-globin gene in KLF2+/+, KLF2+/-, and KLF2-/- embryos; and (C) expression of the embryonic ζ-globin gene in KLF2+/+ and KLF2-/- embryos.

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