Figure 5.
CXCL13 induces integrin-dependent B-cell adhesion to BC1 endothelial cells. B cells were perfused at 0.1 dyne/cm2 on BC1 cell monolayers that were untreated or had been treated with CXCL13. Shear stress was applied at 2 dyne/cm2 for 10 minutes and the remaining adherent B cells were counted. Results are expressed as the percentage of input cells remaining bound. For inhibition studies, B cells were treated with PTX or mAbs to CD11a or CD49d. Data represent the mean ± SD for 3 separate experiments. *P < .01 compared with untreated BC1 cells. **P < .01 compared with vehicle-treated or control IgG-treated B cells.