Figure 6.
Lungs of TMpro/pro mice are diffusely inflamed 36 weeks after infection. Representative lung sections of WT (original magnification × 4, A) and TMpro/pro (original magnification × 4, B) mice 36 weeks after infection, showing more confluent and dense inflammation in TMpro/pro mice than in WT mice. Monocytes and lymphocytes are the dominant inflammatory cell types in WT mice (original magnification × 40, C) compared with large, “foamy” macrophages in TMpro/pro mice (original magnification × 40, D). At this late time point, fibrin(ogen) is still undetectable (original magnification × 20, E-F). Figures are representative of the remaining mice presented in Figure 4 (9/14 TMpro/pro mice and 14/14 WT mice).