Figure 5.
Human engraftment in NOD/SCID mice of Delta1ext-IgG cultured cells. CD34+CD38– cord blood precursors were cultured for 3 weeks with increasing Delta1ext-IgG densities or human control IgG (designated in the figures as Delta1ext-IgG at 0 μg/mL) and transplanted into sublethally irradiated NOD/SCID mice. (A) Percent overall human engraftment (CD45+), (B) percent human lymphoid engraftment, and (C) percent human myeloid engraftment were assessed in bone marrow aspirates from mice at 3, 6, and 10 weeks. Data are the results of 5 independent experiments, with the mean ± SEM.