Clonotypic expansions in patients and healthy controls. The size of pathogenic LGL clones was compared with the most expanded clones found for corresponding VB families in healthy individuals. The figure depicts selective examples for individual patients/healthy controls and VB families. ▦ indicates percent clonotypic expansion within a given VB family (clone/VB). □ indicates percent expansion within the entire CD8⁺ cell population (% clonotypic expansion within a VB family multiplied by VB family contribution to CD8⁺ population; clone/CD8⁺). VB3-restricted clonotypic expansions were found in 6 patients and compared with the average size of the most redundant (expanded) clonotypes within VB3 in 9 healthy controls (a total of 356 CDR3 sequences). VB9-restricted expansions were found in 4 patients and compared with the average size of the most redundant clones for VB9 family studied in 2 healthy donors (a total of 45 CDR3 sequences). VB13-restricted expansions were found in a total of 10 patients and compared with the average size of the most redundant clones for VB13 family detected in 8 healthy controls (a total of 608 CDR3 sequences). A total of 6 patients were found to have VB18-specific immunodominant clonotypes and were compared with the average size of the most redundant clones for VB18 family derived from 8 healthy individuals (a total of 447 CDR3 sequences). In addition, repertoires of mature effector CTL cells (CD8⁺CD57⁺) derived from healthy individuals (n = 2) were studied. Pat no. indicates patient number.