Figure 3.
CDR3 motifs and expansions of immunodominant T-cell clones within VB family and CD8+ population. Pat indicates patient number; CDR3, sequence of the complementarity determining region 3; inv, first 3 invariant AAs of the JB region; VB-JB, restriction of the variable and joining β region of the TCR; imm clone/VB family, expansion of immunodominant, disease-associated T-cell clone within a given TCR VB family; imm clone/CD8+, expansion of immunodominant clone within the entire CD8+ population (clonal expansion within given VB family multiplied by expansion of this VB family within CD8+ cell population); and *, VB family expansion not available.