Spectral karyotyping (SKY) of hTERT-transduced HPV16 E711-20–specific CTL A9-TN. (A) SKY karyogram of a representative metaphase (n = 8) derived from A9-TN, 10 months after hTERT transduction, showing a 47, XY, +X, der(7)t(7;19)(p13;q13.2),+der(14;15)(q10;q10),–15, der(15)t(7;15)(p13;q26.1), der(16)t(1;16)(q21.1;q11.2), der(20)t(17;20)(q11.2;p13) karyotype containing chromosomal translocations. (B) Representative enlargements of the 4 indicated clonal translocations detected in 8 of 8 metaphases, and 1 nonclonal translocation detected in 5 of 8 metaphases, respectively, present at 10 months after hTERT transduction.