High-resolution genome-wide array CGH analysis of HPV16 E711-20–specific CTL A9 and its hTERT-transduced counterpart A9-TN. The array CGH log2 ratios, indicating changes in DNA copy number, obtained using genomic DNA isolated from (A) untransduced A9 and (B) A9-TN at 10 months after hTERT transduction, are depicted for all clones included in the analysis. Gains and losses of genomic sequences are illustrated by an increased or decreased log2 ratio of the respective clones, above or below the average ratio, respectively. The loss of an X chromosome and gain of the Y chromosome served as an internal control.