Kaplan-Meier curves according to NPM1 mutation in the FLT3/ITD-positive and -negative patients. (A) In the FLT3/ITD-positive group, the NPM1 mutation was a favorable prognostic factor for overall survival, but did not affect the relapse risk. (B) In the FLT3/ITD-negative group, the NPM1 mutation did not affect overall survival. The NPM1 mutation tended to be a worse factor for relapse in this group, although it was not statistically significant. Statistical difference was evaluated with the log-rank test.