Response to interferon-α in patients 2 and 3. (A) Morphine equivalent daily dose (MEDD; mg/d) needed to manage pain before and after interferon-α therapy. Patient required 120 mg/d opioids before starting interferon-α. After 2 years, he no longer needs opioids. (B) Bone radiograph of the right femur reveals mixed osteosclerotic and osteolytic lesions before treatment. Ongoing improvement is seen after 2 years of treatment with interferon-α. (C) (Top) Bilateral exophthalmos with chemosis, engorged conjunctival vessels, and inferior scleral show (arrows) at presentation. Loss of eyelashes because of recent chemotherapy is noted. (Bottom) Exophthalmos, chemosis, and inferior scleral show (arrows) resolved after 2 years of interferon-α. Eyelashes have grown back.