EBV-specific T-cell responses in relation to polyclonal proliferative capacity. Panel A indicates the proliferative response to αCD3 mAb expressed in counts per minute (CPM) at 6, 3, and 1 years before NHL or AIDS. • indicates progressors to NHL (NHL) or other AIDS (P); and , slow progressors (SP). The P value of the Mann-Whitney test is given above the graphs. Panels B-D give representative examples of the CD4⁺ T-cell response to EBNA1 and BZLF1 for a progressor to NHL (B; in whom the responses to EBNA1 and BZLF1 were lost before loss of the response to αCD3), a progressor to AIDS (C; in whom the BZLF1-specific response was lost early and EBNA1-specific response parallels the αCD3 response), and a slow progressor (D; in whom no response to BZLF1 was measured and the EBNA1-specific response decreased in parallel with the αCD3 response). Panel E shows the ratio between EBNA1-specific CD4⁺ T-cell responses and general proliferative capacity (in response to αCD3 mAb) indexed to the time point at 6 years before AIDS diagnosis.