Effects of fIX or fXI deficiency on growth and longevity in Plg^–/– mice. (A) Plg null allele and weight. Shown are average weights for 9 Plg^+/+ (□), 19 Plg^+/– (▵), and 14 Plg^–/– (○) mice followed from birth to age 6 months. Error bars are not shown because of space limitations in the figure. (B) Plg null allele and survival. Shown is survival for Plg^+/+ (solid line), Plg^+/– (dotted line), and Plg^–/– (dashed line) mice in panel A. (C) Effect of fIX or fXI deficiency on weight in Plg^–/– mice. Shown are average weights for 19 wild-type (□) and 14 Plg^–/– (○) mice (as in panel A) and 21 Plg^+/+/fIX^–/– (▴), 24 Plg^+/+/fXI^–/– (♦), 24 Plg^–/–/fIX^–/– (♦), and 25 Plg^–/–/fXI^–/– (▴) mice followed from birth to age 6 months. (D) Effect of fIX or fXI deficiency on survival in Plg^–/– mice. Survival is shown for wild-type, Plg^+/+/fIX^–/–, and Plg^+/+/fXI^–/– mice (all represented by solid line) and Plg^–/– (long-dashed line), Plg^–/–/fIX^–/– (short-dashed line), and Plg^–/–/fXI^–/– (dotted line) mice. Average weights in panels A and C are for surviving animals at each time point. Animals with the most significant weight loss die early and are not counted at subsequent time points. Lung fibrosis induced by 0.04 units (E) or 0.08 units (F) of intratracheal bleomycin. Lung fibrosis scores ± SEM were obtained 3 weeks after administration of bleomycin for wild-type (n = 6) and fXI^–/– (n = 5) mice, as described in “Study design.” Results for Plg^–/– mice (n = 6) are shown for comparison in the 0.04 unit experiment.