Influence of chromosomal gains and amplifications on locus-specific gene-expression levels. Changes in gene-expression levels are depicted for each gene (averaged in each cohort) with regard to the locus-specific genetic status (wild-type vs gain vs amplification). Genes are ordered according to their chromosomal position shown on the right. Gene-locus information was obtained from the website for Genes On Sequence Map (Homo sapiens built 33). For genes with more than one microarray element on the Lymphochip, the average expression from different clones was calculated. The black bar on the left indicates the minimally gained region in all cases. The comparison of the expression levels was performed using the ANOVA test. Genes with significant differences (P < .01) are highlighted in red.