Figure 1.
Figure 1. CCR2-/- CD8+ T cells induce less GVHD morbidity and mortality than WT CD8+ T cells. (A,B) Lethally irradiated (1300 cGy) C3FeB6F1 mice received 5 × 106 TCD WT BM cells alone (×; n = 12) or in combination with 3 to 4.5 × 106 WT (▪; n = 31) or CCR2-/- (□; n = 33) CD8+ T cells. Data represent 3 combined experiments. (A) Kaplan-Meier survival curve. (B) Clinical GVHD score (mean ± SEM). (C) Lethally irradiated (1300 cGy) C3FeB6F1 mice received 5 × 106 TCD WT BM cells alone (×;n = 9) or in combination with 2 × 106 WT (▪; n = 18) or CCR2-/- (□; n = 18) splenic T cells. Data represent 2 combined experiments. NS indicates not significant.

CCR2-/- CD8+ T cells induce less GVHD morbidity and mortality than WT CD8+ T cells. (A,B) Lethally irradiated (1300 cGy) C3FeB6F1 mice received 5 × 106 TCD WT BM cells alone (×; n = 12) or in combination with 3 to 4.5 × 106 WT (▪; n = 31) or CCR2-/- (□; n = 33) CD8+ T cells. Data represent 3 combined experiments. (A) Kaplan-Meier survival curve. (B) Clinical GVHD score (mean ± SEM). (C) Lethally irradiated (1300 cGy) C3FeB6F1 mice received 5 × 106 TCD WT BM cells alone (×;n = 9) or in combination with 2 × 106 WT (▪; n = 18) or CCR2-/- (□; n = 18) splenic T cells. Data represent 2 combined experiments. NS indicates not significant.

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