Migration of CCR2^-/- CD8⁺ T cells into gut and liver during GVHD is reduced. Lethally irradiated (1300 cGy) C3FeB6F1 mice received 5 × 10⁶ TCD WT (B6-Ly5.1) BM cells with a mix of 2 × 10⁶ WT (B6-Thy1.1) and 2 × 10⁶ CCR2^-/- CD8⁺ T cells. Organs were harvested at days 6, 14, and 28 after BMT and analyzed with FACS. (A) Small bowel IEL. (B) Liver. (C) Spleen. (D) PLN. (E) MLN. (F) PP. Data represent the mean ± SEM of the percentage of infiltrating WT (▪) or CCR2^-/- (□) CD8⁺ T cells of all donor CD8⁺ T cells excluding BM-derived CD8⁺ T cells. Eight mice were analyzed per time point.