Graft-versus-tumor effect of CCR2^-/- CD8⁺ T cells is intact. (A) B6D2F1 mice were lethally irradiated and subsequently received 5 × 10⁶ TCD WT BM cells alone (×; n = 9), TCD WT BM and 1 × 10³ P815 mastocytoma cells (•; n = 9), or TCD WT BM, 1 × 10³ P815 mastocytoma cells and 3 × 10⁶ WT (▪; n = 18) or CCR2^-/- (□; n = 18) CD8⁺ T cells. Survival was monitored daily; see Table 1 for causes of death. Data represent 2 combined experiments. (B,C) B6D2F1 mice were lethally irradiated and subsequently received 5 × 10⁶ TCD WT BM cells alone (×; n = 5), TCD WT BM and 5 × 10³ P815 TGL mastocytoma cells (•; n = 5), or TCD WT BM, 5 × 10³ P815 TGL mastocytoma cells and 3 × 10⁶ WT (▪; n = 10), or CCR2^-/- (□; n = 10) CD8⁺ T cells. Whole-body bioluminescent signal intensity was determined twice weekly, and mean ± SEM of total flux is shown.