In vitro agonist-induced aggregation measurements of platelets from wt, SLAM^–/–, and SAP^–/– mice. Representative aggregation measurements in PRP obtained from wt (black), SLAM^–/– (A-C), or SAP^–/– (D-F), male (red) or female (blue) mice in response to 2.5 mM murine TRAP (A and D), 10 μg/mL collagen (B and E), and 10 μM ADP (C and F). Traces from wt male and female aggregatory responses were superimposable. Tracings represent aggregation profiles generated from blood pulled from 3 mice repeated at least 5 times.