Analysis of NK cells and cytokines in serum and bronchioalveolar lavage samples from patients with TAP-2 deficiency. (A) Serum samples obtained from patients A, B, and C, their mother, and 9 healthy donors were analyzed by ELISA assays for the detection of MCP-1 (▦), SDF1 (□), IP10 (▪), and secondary lymphoid tissue chemokine (SLC; ▩) chemokines. Results are of 1 representative experiment of 3 experiments performed on serum samples obtained on 3 independent occasions from each donor. (B) MCP-1 (▦) and IL-2 (□) levels in BAL samples obtained from patients A and B were compared with those in BAL samples obtained from 5 controls without underlying pulmonary disease. (C) Purified NK cells from BAL samples obtained from patients A and B were compared with those of BAL samples obtained from 3 immunosuppressed patients with sustained lung infection and inflammation and were analyzed for the expression of HLA-DR, DP, DQ, CCR2, CXCR3, CXCR4, and CXCR1 receptors. ** P < .001 by Student t test. Error bars indicate SD.