Diminished survival and increased tumor incidence in Nfatc3^-/- mice after SL3-3 infection. (A) Survival curves of Nfatc3^-/- (n = 16/16), Nfatc2^-/- (n = 80/88), or wild-type (n = 48/58) (including heterozygotes) BALB/c mice infected with SL3-3. (B) The cumulative incidence of tumor development of Nfatc3^-/- (n = 14/16), Nfatc2^-/- (n = 53/88), and wild-type (n = 38/58) mice based on enlarged lymphoid organs as defined previously (for details, see “Materials and methods”).