SAC and LPS induced IL-12 p40 and p70 production in whole blood cultures. Whole blood (diluted 1:10) from four HIV-infected individuals (closed symbols) and three noninfected controls (open symbols) was cultured in the presence of various concentrations of SAC (A through C) or LPS (D through F ). After 20 hours of culture, supernatants were harvested, and IL-12 p40 (A and D), IL-12 p70 (B and E), and IL-10 (C and F ) concentrations were measured in ELISA. The results of one representative experiment of three are shown.