Fig. 2.
Fig. 2. (A) Genomic sequence of the 2.1-kb Pst I fragment. The initiation codon for each globin is marked with an “M” and an arrow pointing towards the direction of transcription. The exons are boxed and labeled. CCAAT and TATA boxes are underlined (CCAAT with thin and TATA with thick lines). GATA and CACCC motifs are marked with double lines (GATA with thin and CACCC with thick lines). (B) 3′-5′ to 5′-3′ configuration of the globin genes. Arrows indicate the initiation site and direction of transcription for each globin. Black boxes represent the exons (Pst I fragment does not contain the 3′ end of exon 3 of the α globin and exon 3 of the β globin). The 1009 bp of intervening sequences separate the two genes. (C) Intron-exon boundaries in the adult αA1 - and βA1 -globin genes.

(A) Genomic sequence of the 2.1-kb Pst I fragment. The initiation codon for each globin is marked with an “M” and an arrow pointing towards the direction of transcription. The exons are boxed and labeled. CCAAT and TATA boxes are underlined (CCAAT with thin and TATA with thick lines). GATA and CACCC motifs are marked with double lines (GATA with thin and CACCC with thick lines). (B) 3′-5′ to 5′-3′ configuration of the globin genes. Arrows indicate the initiation site and direction of transcription for each globin. Black boxes represent the exons (Pst I fragment does not contain the 3′ end of exon 3 of the α globin and exon 3 of the β globin). The 1009 bp of intervening sequences separate the two genes. (C) Intron-exon boundaries in the adult αA1 - and βA1 -globin genes.

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