IL-2, and IFN-γ production indexed per million cells in culture. Cells were obtained from the spleens of normal and cured animals. CD4⁺ or CD8⁺ T-cell subsets were cultured with irradiated MC-38 for 2 or 5 days. Supernatants from these cultures were used to measure cytokine levels. Similar cytokine production profiles were seen in the CD4⁺ cells of 3 of 3 cured animals studied.