Inhibition of gp120-apoptosis by anti-CD95 neutralizing MoAb (A), by anti-CD95L neutralizing MoAb (B), and by ICE inhibitor (C). Clone 103 (Th1) was triggered to undergo gp120-apoptosis, after preincubation (30 minutes at 37°C) with the indicated doses of anti-CD95 neutralizing MoAb ZB4 (A), anti-CD95L neutralizing MoAb 4H9 (B), or ICE inhibitor (C). ZB4, 4H9, and ICE inhibitor were then maintained throughout treatment with gp120 and anti-gp120 and culture on immobilized anti-TCR MoAb. After 4 hours, apoptosis was determined by TUNEL. gp120-Apoptosis in the absence of inhibitors was 15% to 18%. % inhibition was calculated as indicated in Materials and Methods.