Proportion of mice with RI-AML or RCN B possessing high levels of CSF-1 in relation to latency. Data are from the experiments depicted in Figs 2 and 3. The percentage of mice bearing tumors (RI-AML, ▴; RCN B, ▪) that have circulating CSF-1 concentrations <13.2 ng/mL are plotted against latency periods that have been arbitrarily classed. The total number of mice contributing to each data point is shown in parentheses. By Fisher's exact test, mice with AML had a significantly greater chance of having CSF-1 concentrations <13.2 ng/mL than mice with RCN B (P ≤ .0099 at 8, 10, 11, 12, 13, and 15 months of latency). In mice with AML, there was a direct correlation between age (or latency) and CSF-1 concentration <13.2 ng/mL (r = .7930, P = .0189), whereas in mice with RCN B there was no significant correlation (r = .1570, P = .6649).