Nucleotide and deduced amino acid sequences of the four GPHe(GL) isoforms. (A) Nucleotide sequences of the four GPHe(GL) cDNA species. The GPB sequence from GL is listed for comparison. Nucleotide differences are marked by stars and deleted sequences in the cDNA products by dashes. The new acceptor splice site ACAG is boxed and its upstream pyrimidine-rich sequence indicated by a straight line. Exons are numbered and their boundaries denoted by triangles. Termination codons (TGA) are underlined. (B) Alignment of the deduced amino acid sequences for GPHe(GL) isoforms. Amino acid variations are denoted by stars and deleted sequences by dashes. Gaps interrupting the amino acid sequence pertain to the exon-exon junctions. The total amino acid number of each putative polypeptide is indicated. Note that GPHe-3 and 4 are premature chain termination products because of a shift in the open reading frame.