Fig. 4.
![Fig. 4. Cyotoxicity of recombinant toxins towards normal bone marrow cells. Normal marrow mononuclear cells (106/0.1 mL well) were incubated with DT388–GM-CSF (▵) or GM-CSF–PE38KDEL (○) for 60 hours and pulsed with [3H]-leucine. In (A), the cells were incubated in parallel with the negative control molecules PE38KDEL (•) or DT388-IL2 (▴). In (B), the cells were also incubated with DT388–GM-CSF (▪) or GM-CSF–PE38KDEL (□) in the presence of 20 ng/mL of GM-CSF.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/90/1/10.1182_blood.v90.1.252/5/bl_0029f4.jpeg?Expires=1735546732&Signature=3ZZvIeHftVBTrsJfDJKzSRBeCKg23JOy~0KaKDND91JTi6gdVl59T8~KlLdHaU7IU99KmaeXoz-TeRDevxgTgyqWokndNXW4iA5zHIqunjnCfCB-rDK1k6rz~R0ipVq4XRyH6JuSMpts-RGmN4W3mAelbSm1PuMBRXcI4T-Yzd5SqyR7dPS~iK25sfQBF1mrk4ASuLUJfbiA~bGBUDKJLwzS5Xn2rv-bt~Bve0~xzx7jueHqRbX5DwTUL0MX1q1BE9~aoiBqN6hLXOfQLKTAcR1ShtSYD~bdPhYkv-2TTEtZ5tjDZ2IFe19p5n~hE~cm4OPbqjjGKOG4-fM0xeAbPA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Cyotoxicity of recombinant toxins towards normal bone marrow cells. Normal marrow mononuclear cells (106/0.1 mL well) were incubated with DT388–GM-CSF (▵) or GM-CSF–PE38KDEL (○) for 60 hours and pulsed with [3H]-leucine. In (A), the cells were incubated in parallel with the negative control molecules PE38KDEL (•) or DT388-IL2 (▴). In (B), the cells were also incubated with DT388–GM-CSF (▪) or GM-CSF–PE38KDEL (□) in the presence of 20 ng/mL of GM-CSF.
