Pathohistological features of the tissues of SCID mice engrafted with the transformed Tax-transgenic F8 LGL cell line. (A) Section of a peritoneal tumor located at the site of injection, showing that it is comprised primarily of LGLs (original magnification × 720). (B) Section of a mesenteric lymph node showing massive LGL infiltration, characteristic of diffuse large-cell type lymphoma (original magnification × 1,080). (C) Section of a spleen showing infiltration of LGLs in the left portion with generalized disruption of both the white and red pulp (original magnification × 720). (D) Section of a liver showing infiltration of LGLs into the sinusoid and portal region (open arrows; original magnification × 360). (E) Section of a mock-injected SCID lung showing an intrapulmonary bronchus with associated epithelium and normal alveolar ducts and alveoli (original magnification × 360). (F ) Lung section from an LGL-engrafted SCID mouse showing massive infiltration of LGLs into the bronchus epithelium and alveoli septa (original magnification × 360). (G) Peripheral blood smear from a mock-injected SCID mouse showing a paucity of circulating lymphocytes and neutrophils (original magnification × 360). (H) Peripheral blood smear from an LGL-engrafted SCID mouse demonstrating LGL lymphocytosis and neutrophilia (original magnification × 720). (I) Higher magnification of (H) showing morphologic characteristics of the LGLs (original magnification × 2,100).