Fig. 2.
Expansion of BMC from NTG and rCD44v4-v7 TG donors in the syngeneic and the allogeneic host. Lethally irradiated (850 R) syngeneic C57BL/6 and irradiated (300 R) allogeneic BALB/c SCID mice were reconstituted with 5 × 106 BMC from NTG or from rCD44v4-v7 TG C57BL/6 mice. The reconstituted mice received either 200 μg control (3-9) or anti-rCD44v6 (1.1ASML) IgG1, IV. Injections of IgG1 were repeated twice per week. Mice were killed after 1 to 6 weeks. The numbers of cells (mean ± SD) in central and peripheral lymphoid organs of 3 mice/group are shown; significant differences between NTG and TG BMC (P ≤ .01) are indicated by an asterisk.